Version 5.4
Bos taurus Gene: TGFBI
Summary
InnateDB Gene IDBG-645854.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFBI
Gene Name transforming growth factor-beta-induced protein ig-h3 precursor
Synonyms MP70; MP78
Species Bos taurus
Ensembl Gene ENSBTAG00000009513
Encoded Proteins
IDBP-698611
transforming growth factor, beta-induced, 68kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120708:
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:49059242-49095515
Strand Forward strand
Band
Transcripts
ENSBTAT00000012519 ENSBTAP00000012519
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005802 trans-Golgi network
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120708
View Gene Order
ENSMUSG00000035493
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
KEGG
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin2_pathway
Beta2 integrin cell surface interactions
integrin3_pathway
Beta3 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL F1MBS3
UniProt Splice Variant
Entrez Gene 539596
UniGene Bt.46833
RefSeq NM_001205402
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020359 DAAA02020360 DAAA02020361
GenPept
RNA Seq Atlas 539596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca