InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MST1R

Summary

InnateDB Gene

IDBG-645881.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MST1R

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015046

Encoded Proteins

IDBP-698644

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18684919

[Homo sapiens] MST1R regulates endotoxin-induced innate immune responses by regulating the production of and response to IFNG (IFN-gamma).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164078:
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:50928327-50941427

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020028

ENSBTAP00000020028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007275	multicellular organismal development
GO:0009615	response to virus
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0001725	stress fiber
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000164078

View Gene Order

ENSMUSG00000032584

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_1

Alpha6Beta4Integrin pathway

REACTOME

KEGG

INOH

PID NCI

a6b1_a6b4_integrin_pathway

a6b1 and a6b4 Integrin signaling

amb2_neutrophils_pathway

amb2 Integrin signaling

Cross-References

SwissProt

TrEMBL

E1BCZ6

UniProt Splice Variant

Entrez Gene

525504

UniGene

Bt.24706

RefSeq

XM_002697035 XM_603857

HUGO

HGNC:7381

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02054416

GenPept

RNA Seq Atlas

525504