Bos taurus Gene: CDC23 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-645929.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | CDC23 | ||||||||||||||||
Gene Name | Cell division cycle protein 23 homolog | ||||||||||||||||
Synonyms | APC8 | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000008759 | ||||||||||||||||
Encoded Proteins |
Cell division cycle protein 23 homolog
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094880:
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 7:51223146-51243230 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
Regulation of APC/C activators between G1/S and early anaphase pathway
M Phase pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Cell Cycle, Mitotic pathway
Phosphorylation of the APC/C pathway
Cell Cycle pathway
Cellular Senescence pathway
Mitotic Spindle Checkpoint pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Regulation of mitotic cell cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Cell Cycle Checkpoints pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C:Cdc20 mediated degradation of Securin pathway
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KEGG | |||||||||||||||||
INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
TGF_beta_Receptor pathway
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REACTOME |
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Separation of Sister Chromatids pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular responses to stress pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Cell Cycle pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular Senescence pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Mitotic Metaphase and Anaphase pathway
Phosphorylation of the APC/C pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Mitotic Anaphase pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
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KEGG |
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | A1A4R8 | ||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 512651 | ||||||||||||||||
UniGene | Bt.1176 | ||||||||||||||||
RefSeq | NM_001080266 XM_005209368 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC126843 | ||||||||||||||||
GenPept | AAI26844 | ||||||||||||||||
RNA Seq Atlas | 512651 | ||||||||||||||||