Bos taurus Gene: APEX1 | |||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-646052.3 | ||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
Gene Symbol | APEX1 | ||||||||||||||||||||||||||||||||||||||||
Gene Name | DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial | ||||||||||||||||||||||||||||||||||||||||
Synonyms | APEN; BAP1; REF-1 | ||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000002745 | ||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
DNA-(apurinic or apyrimidinic site) lyase
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100823:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008] Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5\' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 10:26706595-26709174 | ||||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||||
REACTOME |
Homologous Recombination Repair pathway
S Phase pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Extension of Telomeres pathway
Transcription-coupled NER (TC-NER) pathway
DNA Replication pathway
Telomere Maintenance pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Nucleotide Excision Repair pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Displacement of DNA glycosylase by APE1 pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Processive synthesis on the lagging strand pathway
Processive synthesis on the C-strand of the telomere pathway
Synthesis of DNA pathway
Cell Cycle pathway
DNA Repair pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Lagging Strand Synthesis pathway
Mismatch Repair pathway
Resolution of D-loop structures pathway
Removal of DNA patch containing abasic residue pathway
Base Excision Repair pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Chromosome Maintenance pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of D-loop structures through Holliday junction intermediates pathway
Double-Strand Break Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
DNA strand elongation pathway
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KEGG | |||||||||||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||
NETPATH |
TSH pathway
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REACTOME |
Processive synthesis on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Processive synthesis on the lagging strand pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Resolution of D-loop structures through Holliday junction intermediates pathway
Displacement of DNA glycosylase by APE1 pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Removal of DNA patch containing abasic residue pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
DNA Replication pathway
Synthesis of DNA pathway
Homologous Recombination Repair pathway
Resolution of Abasic Sites (AP sites) pathway
S Phase pathway
Chromosome Maintenance pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Double-Strand Break Repair pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of D-loop structures pathway
Base Excision Repair pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Processive synthesis on the lagging strand pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Transcription-coupled NER (TC-NER) pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Displacement of DNA glycosylase by APE1 pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
DNA strand elongation pathway
DNA Replication pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Global Genomic NER (GG-NER) pathway
Double-Strand Break Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Resolution of D-loop structures through Holliday junction intermediates pathway
Removal of DNA patch containing abasic residue pathway
Resolution of D-loop structures pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Processive synthesis on the C-strand of the telomere pathway
Lagging Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Homologous Recombination Repair pathway
S Phase pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
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KEGG |
Base excision repair pathway
Base excision repair pathway
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INOH | |||||||||||||||||||||||||||||||||||||||||
PID NCI |
HIF-2-alpha transcription factor network
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Cross-References | |||||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
UniGene | Bt.1302 | ||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_176609 | ||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||