Version 5.4
| Bos taurus Gene: CD14 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-646064.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | CD14 | ||||||||||||||||
| Gene Name | monocyte differentiation antigen CD14 precursor | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000015032 | ||||||||||||||||
| Encoded Proteins |
monocyte differentiation antigen CD14 precursor
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||
| Summary |
[Homo sapiens] CD14 co-receptor participates with toll-like receptors (TLRs) in the response of microglial cells to fibrillar forms of beta-amyloid, contributing to microglial activation.
[Homo sapiens] CD14 recognizes necrotic cells in addition to LPS, PG, apoptotic cells, and lipids, suggesting that it might be a universal adaptor for damage-associated molecular pattern (DAMP) and pathogen-associated molecular patterns (PAMP).
[Homo sapiens] CD14 is a molecule that binds to lipopolysaccharide (LPS) and facilitates its signalling by helping TLR4-LY96 to sense and signal the presence of LPS.
[Homo sapiens] CD14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal TLR7/TLR9 activation.
[Homo sapiens] CD14 acts as an adaptor molecule for the immune recognition of salmonella curli fibers.
[Mus musculus] Cd14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal Tlr7/Tlr9 activation.
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| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170458:
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 7:53446106-53448979 | ||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
TRAF6 mediated induction of TAK1 complex pathway
IKK complex recruitment mediated by RIP1 pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRIF-mediated programmed cell death pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Transfer of LPS from LBP carrier to CD14 pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
TRAF6 mediated induction of TAK1 complex pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll-Like Receptors Cascades pathway
TRIF-mediated programmed cell death pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Transfer of LPS from LBP carrier to CD14 pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
Hematopoietic cell lineage pathway
Pathogenic Escherichia coli infection pathway
MAPK signaling pathway pathway
Toll-like receptor signaling pathway pathway
Amoebiasis pathway
Phagosome pathway
Hematopoietic cell lineage pathway
Toll-like receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Amoebiasis pathway
Phagosome pathway
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| INOH |
Toll-like receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
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| PID NCI |
Beta1 integrin cell surface interactions
Alpha4 beta1 integrin signaling events
Endogenous TLR signaling
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| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | |||||||||||||||||
| UniGene | Bt.4285 | ||||||||||||||||
| RefSeq | NM_174008 XM_005209429 | ||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | |||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||