Version 5.4
| Bos taurus Gene: FGF1 | |||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-646137.3 | ||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
| Gene Symbol | FGF1 | ||||||||||||||||||||||||||||||||||||
| Gene Name | Fibroblast growth factor 1 Endothelial cell growth factor beta Endothelial cell growth factor alpha | ||||||||||||||||||||||||||||||||||||
| Synonyms | ECGF; FGF-1 | ||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000005198 | ||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
Heparin-binding growth factor 1Endothelial cell growth factor betaEndothelial cell growth factor alpha
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| Protein Structure | |||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113578:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:55508007-55601836 | ||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||
| REACTOME |
DAP12 interactions pathway
Insulin receptor signalling cascade pathway
Signaling by FGFR1 mutants pathway
Signaling by EGFR pathway
GAB1 signalosome pathway
Negative regulation of FGFR signaling pathway
FGFR1 ligand binding and activation pathway
SHC-mediated cascade pathway
FGFR4 ligand binding and activation pathway
IRS-related events triggered by IGF1R pathway
FGFR2b ligand binding and activation pathway
Signaling by PDGF pathway
FGFR3c ligand binding and activation pathway
Signaling by ERBB4 pathway
FGFR ligand binding and activation pathway
Signaling by FGFR pathway
Signaling by FGFR mutants pathway
FGFR2 ligand binding and activation pathway
IRS-related events pathway
FGFR2c ligand binding and activation pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
FGFR3 ligand binding and activation pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
IRS-mediated signalling pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
FGFR3b ligand binding and activation pathway
Signal Transduction pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Signaling by EGFR in Cancer pathway
PI-3K cascade pathway
Signaling by FGFR3 mutants pathway
Signaling by activated point mutants of FGFR3 pathway
Activated point mutants of FGFR2 pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
Signaling by activated point mutants of FGFR1 pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
FGFR1b ligand binding and activation pathway
Phospholipase C-mediated cascade pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
FRS2-mediated cascade pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Signaling by FGFR2 mutants pathway
Fc epsilon receptor (FCERI) signaling pathway
FGFR1c ligand binding and activation pathway
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| KEGG | |||||||||||||||||||||||||||||||||||||
| INOH | |||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Negative regulation of FGFR signaling pathway
Phospholipase C-mediated cascade pathway
SHC-mediated cascade pathway
PI-3K cascade pathway
FRS2-mediated cascade pathway
FGFR2b ligand binding and activation pathway
FGFR2c ligand binding and activation pathway
FGFR3b ligand binding and activation pathway
FGFR3c ligand binding and activation pathway
FGFR1c ligand binding and activation pathway
FGFR1b ligand binding and activation pathway
FGFR4 ligand binding and activation pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activated point mutants of FGFR2 pathway
Signaling by activated point mutants of FGFR1 pathway
Signaling by activated point mutants of FGFR3 pathway
Signaling by FGFR mutants pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signaling by FGFR3 mutants pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
FGFR3 ligand binding and activation pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
FGFR1 ligand binding and activation pathway
Disease pathway
Innate Immune System pathway
FGFR3 ligand binding and activation pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Signaling by Insulin receptor pathway
FGFR2b ligand binding and activation pathway
FGFR1b ligand binding and activation pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
FGFR3c ligand binding and activation pathway
FGFR2 ligand binding and activation pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Negative regulation of FGFR signaling pathway
FGFR4 ligand binding and activation pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
FGFR ligand binding and activation pathway
Signaling by EGFR pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
FGFR1c ligand binding and activation pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Phospholipase C-mediated cascade pathway
PI3K Cascade pathway
Signaling by FGFR2 mutants pathway
Activated point mutants of FGFR2 pathway
Signaling by activated point mutants of FGFR1 pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
FGFR3b ligand binding and activation pathway
Signaling by FGFR mutants pathway
Signaling by FGFR1 mutants pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
SHC-mediated cascade pathway
GAB1 signalosome pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
FGFR2c ligand binding and activation pathway
Signaling by FGFR3 mutants pathway
Signaling by activated point mutants of FGFR3 pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
FGFR1 ligand binding and activation pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Melanoma pathway
Pathways in cancer pathway
Melanoma pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Pathways in cancer pathway
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| INOH |
FGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
FGF signaling pathway
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| Cross-References | |||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| UniGene | Bt.5038 | ||||||||||||||||||||||||||||||||||||
| RefSeq | NM_174055 | ||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||