InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACTC1

Summary

InnateDB Gene

IDBG-646169.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTC1

Gene Name

Actin, alpha cardiac muscle 1

Synonyms

ACTC

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005714

Encoded Proteins

IDBP-698946

Actin, alpha cardiac muscle 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159251:
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:30361781-30367052

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007504

ENSBTAP00000007504

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017022	myosin binding

Biological Process

GO:0006200	ATP catabolic process
GO:0030048	actin filament-based movement
GO:0030240	skeletal muscle thin filament assembly
GO:0031032	actomyosin structure organization
GO:0033275	actin-myosin filament sliding
GO:0043066	negative regulation of apoptotic process
GO:0055003	cardiac myofibril assembly
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060047	heart contraction
GO:0070252	actin-mediated cell contraction

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0016020	membrane
GO:0030017	sarcomere
GO:0031674	I band
GO:0042643	actomyosin, actin part
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle