Bos taurus Gene: BT.43608 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-646193.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | BT.43608 | ||||||||||||||||
Gene Name | serine protease inhibitor Kazal-type 5 precursor | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000019140 | ||||||||||||||||
Encoded Proteins |
serine protease inhibitor Kazal-type 5
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] SPINK5 binds to antimicrobial peptide dermcidin (DCD) and is involved in the trafficking of DCD in the epidermis.
[Mus musculus] Spink5 binds to antimicrobial peptide dermcidin (DCD) and is involved in the trafficking of DCD in the epidermis. (Demonstrated in human)
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133710:
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 7:61321641-61405244 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | F1MJH0 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 526637 | ||||||||||||||||
UniGene | Bt.110128 Bt.43608 Bt.61582 | ||||||||||||||||
RefSeq | NM_001102102 | ||||||||||||||||
HUGO | HGNC:15464 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02020581 DAAA02020582 DAAA02020583 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 526637 | ||||||||||||||||