Version 5.4
Bos taurus Gene: EIF2AK4
Summary
InnateDB Gene IDBG-646199.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2AK4
Gene Name Uncharacterized protein
Synonyms Gcn2-like
Species Bos taurus
Ensembl Gene ENSBTAG00000014351
Encoded Proteins
IDBP-698984
eukaryotic translation initiation factor 2 alpha kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128829:
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:35707709-35804772
Strand Forward strand
Band
Transcripts
ENSBTAT00000019083 ENSBTAP00000019083
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0006446 regulation of translational initiation
GO:0006468 protein phosphorylation
GO:0009267 cellular response to starvation
GO:0017148 negative regulation of translation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043558 regulation of translational initiation in response to stress
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000128829
View Gene Order
ENSMUSG00000005102
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05160
Hepatitis C pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BAL6
UniProt Splice Variant
Entrez Gene 513829
UniGene Bt.109730 Bt.109888 Bt.109894
RefSeq XM_001787661 XM_002690785 XM_005192398 XM_005211623
HUGO HGNC:19687
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028541
GenPept
RNA Seq Atlas 513829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca