Version 5.4
Bos taurus Gene: BT.18085
Summary
InnateDB Gene IDBG-646200.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.18085
Gene Name sterol regulatory element-binding protein cleavage-activating protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015782
Encoded Proteins
IDBP-698981
sterol regulatory element-binding protein cleavage-activating protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114650:
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:52768660-52818675
Strand Forward strand
Band
Transcripts
ENSBTAT00000020961 ENSBTAP00000020961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008158 hedgehog receptor activity
Biological Process
GO:0001666 response to hypoxia
GO:0008203 cholesterol metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0032868 response to insulin
GO:0032933 SREBP signaling pathway
GO:0042304 regulation of fatty acid biosynthetic process
GO:0045540 regulation of cholesterol biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114650
View Gene Order
ENSMUSG00000032485
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MQ33
UniProt Splice Variant
Entrez Gene 507878
UniGene Bt.18085
RefSeq NM_001101889
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054449
GenPept
RNA Seq Atlas 507878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca