Version 5.4
Bos taurus Gene: BT.25661
Summary
InnateDB Gene IDBG-646208.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.25661
Gene Name mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007237
Encoded Proteins
IDBP-698991
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156970:
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:35903021-35958915
Strand Forward strand
Band
Transcripts
ENSBTAT00000009521 ENSBTAP00000009521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0034501 protein localization to kinetochore
GO:0071459 protein localization to chromosome, centromeric region
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000778 condensed nuclear chromosome kinetochore
GO:0000940 condensed chromosome outer kinetochore
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000156970
View Gene Order
ENSMUSG00000040084
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_222875
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_222604
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_241408
M Phase pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_248037
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_234036
Mitotic Spindle Checkpoint pathway
REACT_202512
Mitotic Anaphase pathway
REACT_263475
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
KEGG
hsa04110
Cell cycle pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.25661
RefSeq NM_001145173 XM_003582704 XM_005192399 XM_005211589
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca