InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.74208

Summary

InnateDB Gene

IDBG-646273.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.74208

Gene Name

beta-type platelet-derived growth factor receptor precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002804

Encoded Proteins

IDBP-699063

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113721:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:63496230-63532702

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061140

ENSBTAP00000053664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005019	platelet-derived growth factor beta-receptor activity
GO:0005102	receptor binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0038085	vascular endothelial growth factor binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001894	tissue homeostasis
GO:0006468	protein phosphorylation
GO:0006807	nitrogen compound metabolic process
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010863	positive regulation of phospholipase C activity
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030325	adrenal gland development
GO:0030335	positive regulation of cell migration
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0046488	phosphatidylinositol metabolic process
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048705	skeletal system morphogenesis
GO:0048745	smooth muscle tissue development
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0060326	cell chemotaxis

Cellular Component

GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000113721

View Gene Order

ENSMUSG00000024620

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_75829

PIP3 activates AKT signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_12464

PI3K/AKT activation pathway

REACT_12578

GAB1 signalosome pathway

REACT_9417

Signaling by EGFR pathway

REACT_115961

PI3K events in ERBB4 signaling pathway

REACT_115596

Signaling by ERBB4 pathway

REACT_116008

PI3K events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21270

PI-3K cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_111040

Signaling by SCF-KIT pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_147727

Constitutive PI3K/AKT Signaling in Cancer pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_163769

Role of LAT2/NTAL/LAB on calcium mobilization pathway

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_111102

Signal Transduction pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_147723

PI3K/AKT Signaling in Cancer pathway

REACT_118773

Signaling by the B Cell Receptor (BCR) pathway

REACT_118638

Downstream signaling events of B Cell Receptor (BCR) pathway

REACT_116125

Disease pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04540

Gap junction pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa05214

Glioma pathway

hsa05215

Prostate cancer pathway

hsa04510

Focal adhesion pathway

hsa04020

Calcium signaling pathway pathway

hsa05200

Pathways in cancer pathway

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04020

Calcium signaling pathway pathway

mmu04540

Gap junction pathway

mmu05218

Melanoma pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04010

MAPK signaling pathway pathway

mmu05214

Glioma pathway

mmu05215

Prostate cancer pathway

mmu04510

Focal adhesion pathway

mmu05200

Pathways in cancer pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

INOH website

PDGF signaling pathway pathway

PID NCI

s1p_s1p1_pathway

S1P1 pathway

ptp1bpathway

Signaling events mediated by PTP1B

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

nectin_pathway

Nectin adhesion pathway

myc_represspathway

Validated targets of C-MYC transcriptional repression

tcptp_pathway

Signaling events mediated by TCPTP

s1p_s1p3_pathway

S1P3 pathway

shp2_pathway

SHP2 signaling

pdgf_pathway

PDGF receptor signaling network

integrin3_pathway

Beta3 integrin cell surface interactions

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

TrEMBL

F1N759

UniProt Splice Variant

Entrez Gene

527165

UniGene

Bt.27665

RefSeq

NM_001075896 XM_005209589 XM_005209590

HUGO

HGNC:8804

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02020625

GenPept

RNA Seq Atlas

527165