InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNIP1

Summary

InnateDB Gene

IDBG-646318.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNIP1

Gene Name

TNFAIP3-interacting protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012671

Encoded Proteins

IDBP-699109

TNFAIP3-interacting protein 1

IDBP-699110

TNFAIP3-interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21606507

[Homo sapiens] TNIP1 interacts with polyubiquitin to limit the activation of TLR-MYD88 signalling pathway and prevents autoimmunity. (Demonstrated in murine model)

PMID 22011580

[Homo sapiens] TNIP1 is an essential anti-inflammatory component of TLR-signalling pathways that controls CEBPB activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease. (Demonstrated in mice)

PMID 21606507

[Mus musculus] Tnip1 interacts with polyubiquitin to limit the activation of Tlr-Myd88 signalling pathway and prevents autoimmunity.

PMID 22011580

[Mus musculus] Tnip1 is an essential anti-inflammatory component of TLR-signalling pathways that controls Cebpb activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145901:
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:64295657-64339418

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016836	ENSBTAP00000016836
ENSBTAT00000042864	ENSBTAP00000040474

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005488	binding
GO:0005515	protein binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0007159	leukocyte cell-cell adhesion
GO:0009101	glycoprotein biosynthetic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000145901

View Gene Order

ENSMUSG00000020400

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1N5V5 Q3ZC37

UniProt Splice Variant

Entrez Gene

526103

UniGene

Bt.49602

RefSeq

NM_001024554 XM_005209581 XM_005209582 XM_005209584

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102932 DAAA02020636 DAAA02020637

GenPept

AAI02933

RNA Seq Atlas

526103