Version 5.4
Bos taurus Gene: SLC6A1
Summary
InnateDB Gene IDBG-646319.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A1
Gene Name sodium- and chloride-dependent GABA transporter 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005857
Encoded Proteins
IDBP-699112
sodium- and chloride-dependent GABA transporter 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157103:
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:55695783-55714644
Strand Forward strand
Band
Transcripts
ENSBTAT00000007699 ENSBTAP00000007699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005332 gamma-aminobutyric acid:sodium symporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0015812 gamma-aminobutyric acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000157103
View Gene Order
ENSMUSG00000030310
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_23910
Reuptake of GABA pathway
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_245631
GABA synthesis, release, reuptake and degradation pathway
REACT_253228
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_247910
Reuptake of GABA pathway
REACT_250087
Neurotransmitter Release Cycle pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_259290
Neuronal System pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0JND1
UniProt Splice Variant
Entrez Gene 407118
UniGene Bt.29847
RefSeq NM_001077836 XM_005223025
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126623 DAAA02054551
GenPept AAI26624
RNA Seq Atlas 407118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca