InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GM2A

Summary

InnateDB Gene

IDBG-646327.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GM2A

Gene Name

ganglioside GM2 activator precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021829

Encoded Proteins

IDBP-699128

GM2 ganglioside activator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196743:
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:64499096-64511547

Strand

Forward strand

Band

Transcripts

ENSBTAT00000029099

ENSBTAP00000029099

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004563	beta-N-acetylhexosaminidase activity
GO:0008047	enzyme activator activity

Biological Process

GO:0006689	ganglioside catabolic process
GO:0007611	learning or memory
GO:0009313	oligosaccharide catabolic process
GO:0019915	lipid storage
GO:0050877	neurological system process
GO:0050885	neuromuscular process controlling balance