InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MSH3

Summary

InnateDB Gene

IDBG-646483.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH3

Gene Name

DNA mismatch repair protein Msh3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007684

Encoded Proteins

IDBP-699311

DNA mismatch repair protein Msh3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113318:
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:83040940-83227242

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010107

ENSBTAP00000010107

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000403	Y-form DNA binding
GO:0000404	heteroduplex DNA loop binding
GO:0000406	double-strand/single-strand DNA junction binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0019237	centromeric DNA binding
GO:0019899	enzyme binding
GO:0030983	mismatched DNA binding
GO:0032139	dinucleotide insertion or deletion binding
GO:0032142	single guanine insertion binding
GO:0032181	dinucleotide repeat insertion binding
GO:0032357	oxidized purine DNA binding

Biological Process

GO:0000710	meiotic mismatch repair
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0007131	reciprocal meiotic recombination
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0043570	maintenance of DNA repeat elements
GO:0045910	negative regulation of DNA recombination
GO:0051096	positive regulation of helicase activity