Bos taurus Gene: RGMB | |||||||||
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Summary | |||||||||
InnateDB Gene | IDBG-646600.3 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | RGMB | ||||||||
Gene Name | Uncharacterized protein | ||||||||
Synonyms | |||||||||
Species | Bos taurus | ||||||||
Ensembl Gene | ENSBTAG00000011864 | ||||||||
Encoded Proteins |
RGM domain family, member B
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Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
InnateDB Annotation from Orthologs | |||||||||
Summary |
[Homo sapiens] RGMB is highly expressed in macrophages and negatively regulates IL6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway. (Demonstrated in murine model)
[Mus musculus] Rgmb is highly expressed in macrophages and negatively regulates Il6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway.
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Entrez Gene | |||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174136:
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009] |
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Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 7:100425877-100446422 | ||||||||
Strand | Forward strand | ||||||||
Band | |||||||||
Transcripts |
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Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||
NETPATH | |||||||||
REACTOME |
Netrin-1 signaling pathway
Developmental Biology pathway
Axon guidance pathway
Netrin-1 signaling pathway
Axon guidance pathway
Developmental Biology pathway
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KEGG | |||||||||
INOH | |||||||||
PID NCI | |||||||||
Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | F1MFY9 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 540954 | ||||||||
UniGene | Bt.105463 | ||||||||
RefSeq | XM_002689413 XM_613847 | ||||||||
HUGO | HGNC:26896 | ||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | DAAA02021391 | ||||||||
GenPept | |||||||||
RNA Seq Atlas | 540954 | ||||||||