Bos taurus Gene: CYP19A1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-646660.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CYP19A1 | ||||||||||||||||||
Gene Name | cytochrome P450 19A1 | ||||||||||||||||||
Synonyms | CYP19; CYP19P1 | ||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000014890 | ||||||||||||||||||
Encoded Proteins |
cytochrome P450 19A1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137869:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 10:59227895-59282939 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Estrogen biosynthesis pathway
Endogenous sterols pathway
Metabolism of lipids and lipoproteins pathway
Metabolism of steroid hormones and vitamin D pathway
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
Cytochrome P450 - arranged by substrate type pathway
Phase 1 - Functionalization of compounds pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Endogenous sterols pathway
Estrogen biosynthesis pathway
Biological oxidations pathway
Metabolism of steroid hormones and vitamin D pathway
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KEGG |
Steroid hormone biosynthesis pathway
Steroid hormone biosynthesis pathway
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INOH |
Tryptophan degradation pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | F2Z4F2 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 281740 | ||||||||||||||||||
UniGene | Bt.4447 | ||||||||||||||||||
RefSeq | NM_174305 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | DAAA02029028 DAAA02029029 DAAA02029030 DAAA02029031 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 281740 | ||||||||||||||||||