InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GATM

Summary

InnateDB Gene

IDBG-646693.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GATM

Gene Name

Glycine amidinotransferase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005586

Encoded Proteins

IDBP-699519

Glycine amidinotransferase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171766:
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:65325342-65341352

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007338

ENSBTAP00000007338

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015068	glycine amidinotransferase activity
GO:0016740	transferase activity
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Biological Process

GO:0006601

creatine biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome