InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.87811

Summary

InnateDB Gene

IDBG-646724.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.87811

Gene Name

homeobox protein OTX2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014741

Encoded Proteins

IDBP-699552

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165588:
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:69458818-69462865

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019616

ENSBTAP00000019616

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0007492	endoderm development
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0022037	metencephalon development
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0032525	somite rostral/caudal axis specification
GO:0040019	positive regulation of embryonic development
GO:0042472	inner ear morphogenesis
GO:0042706	eye photoreceptor cell fate commitment
GO:0045165	cell fate commitment
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048663	neuron fate commitment
GO:0048664	neuron fate determination
GO:0048852	diencephalon morphogenesis
GO:0048856	anatomical structure development
GO:0090009	primitive streak formation
GO:2000543	positive regulation of gastrulation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030426	growth cone
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000165588

View Gene Order

ENSMUSG00000021848

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.87811

RefSeq

NM_001193201 XM_005211839 XM_005211840

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas