InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAX

Summary

InnateDB Gene

IDBG-646780.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAX

Gene Name

protein max

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017994

Encoded Proteins

IDBP-699614

protein max

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125952:
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:77515539-77541594

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023939

ENSBTAP00000023939

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity