InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FUT8

Summary

InnateDB Gene

IDBG-646782.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT8

Gene Name

alpha-(1,6)-fucosyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019819

Encoded Proteins

IDBP-699615

alpha-(1,6)-fucosyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033170:
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:77989585-78165236

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026406

ENSBTAP00000026406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008424	glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046921	alpha-(1->6)-fucosyltransferase activity

Biological Process

GO:0006486	protein glycosylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007585	respiratory gaseous exchange
GO:0016477	cell migration
GO:0018279	protein N-linked glycosylation via asparagine
GO:0033578	protein glycosylation in Golgi
GO:0036065	fucosylation
GO:0036071	N-glycan fucosylation
GO:0043112	receptor metabolic process
GO:0046368	GDP-L-fucose metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome