Version 5.4
Bos taurus Gene: BT.52419
Summary
InnateDB Gene IDBG-646845.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.52419
Gene Name ubiquinone biosynthesis monooxygenase COQ6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020331
Encoded Proteins
IDBP-699684
ubiquinone biosynthesis monooxygenase COQ6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119723:
The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:85725236-85740089
Strand Forward strand
Band
Transcripts
ENSBTAT00000027093 ENSBTAP00000027093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006744 ubiquinone biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119723
View Gene Order
ENSMUSG00000021235
View Gene Order
Pathways
NETPATH
REACTOME
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_227457
Ubiquinol biosynthesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160111
Ubiquinol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196568
Ubiquinol biosynthesis pathway
KEGG
hsa00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
mmu00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q2KIL4
TrEMBL
UniProt Splice Variant
Entrez Gene 511624
UniGene Bt.52419
RefSeq NM_001046093
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112594 DAAA02029604
GenPept AAI12595
RNA Seq Atlas 511624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca