InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AGTR1

Summary

InnateDB Gene

IDBG-647315.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGTR1

Gene Name

Type-1 angiotensin II receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000045633

Encoded Proteins

IDBP-700148

Type-1 angiotensin II receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144891:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:120403009-120404088

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000063575

ENSBTAP00000055053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001596	angiotensin type I receptor activity
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0031711	bradykinin receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001822	kidney development
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007266	Rho protein signal transduction
GO:0010873	positive regulation of cholesterol esterification
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032430	positive regulation of phospholipase A2 activity
GO:0038166	angiotensin-activated signaling pathway
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326	cell chemotaxis
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway