InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FZD2

Summary

InnateDB Gene

IDBG-647894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020590

Encoded Proteins

IDBP-700680

frizzled family receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180340:
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44954982-44956760

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027434

ENSBTAP00000056239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007608	sensory perception of smell
GO:0016055	Wnt signaling pathway
GO:0030825	positive regulation of cGMP metabolic process
GO:0030855	epithelial cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060119	inner ear receptor cell development
GO:0060412	ventricular septum morphogenesis
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure