Bos taurus Gene: HTR1B
InnateDB Gene IDBG-647928.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR1B
Gene Name Uncharacterized protein
Species Bos taurus
Ensembl Gene ENSBTAG00000037429
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135312:
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:17302418-17303587
Strand Reverse strand
ENSBTAT00000061041 ENSBTAP00000053759
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0008144 drug binding
GO:0051378 serotonin binding
Biological Process
GO:0002031 G-protein coupled receptor internalization
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007631 feeding behavior
GO:0014063 negative regulation of serotonin secretion
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0035690 cellular response to drug
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0046849 bone remodeling
GO:0050795 regulation of behavior
GO:0071312 cellular response to alkaloid
GO:0071502 cellular response to temperature stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
G alpha (i) signalling events pathway
Serotonin receptors pathway
Amine ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Amine ligand-binding receptors pathway
Serotonin receptors pathway
GPCR ligand binding pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
Neuroactive ligand-receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
TrEMBL A1Y9Q0 A1Y9Q1 A1Y9Q2 A1Y9Q3 F1MGM3 Q8MI14
UniProt Splice Variant
Entrez Gene 317707
RefSeq XM_005192387 XM_005210681
EMBL AJ491859 DAAA02025338 DQ862861 DQ862862 DQ862863 DQ862864 DQ862865
GenPept ABI81480 ABI81481 ABI81482 ABI81483 ABI81484 CAD37204
RNA Seq Atlas 317707