Homo sapiens Gene: RAN
Summary
InnateDB Gene IDBG-64798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAN
Gene Name RAN, member RAS oncogene family
Synonyms ARA24; Gsp1; TC4;
Species Homo sapiens
Ensembl Gene ENSG00000132341
Encoded Proteins
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy\'s disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy\'s disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:130871879-130877678
Strand Forward strand
Band q24.33
Transcripts
ENST00000392369 ENSP00000376176
ENST00000392367 ENSP00000376174
ENST00000448750 ENSP00000396127
ENST00000477395
ENST00000464211
ENST00000543796 ENSP00000446215
ENST00000536606 ENSP00000437950
ENST00000537745
ENST00000541630 ENSP00000441210
ENST00000535090 ENSP00000444042
ENST00000541679 ENSP00000483687
ENST00000539498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 150 [view]
Protein-Protein 148 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
GO:0044822 poly(A) RNA binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006184 GTP catabolic process
GO:0006259 DNA metabolic process
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007052 mitotic spindle organization
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007286 spermatid development
GO:0010467 gene expression
GO:0015031 protein transport
GO:0016032 viral process
GO:0019058 viral life cycle
GO:0030521 androgen receptor signaling pathway
GO:0032092 positive regulation of protein binding
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0075733 intracellular transport of virus
Cellular Component
GO:0000785 chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0042470 melanosome
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
TCR pathway
REACTOME
Influenza Infection pathway
Metabolism of lipids and lipoproteins pathway
MicroRNA (miRNA) biogenesis pathway
Late Phase of HIV Life Cycle pathway
Transcriptional regulation by small RNAs pathway
NEP/NS2 Interacts with the Cellular Export Machinery pathway
HIV Life Cycle pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Rev-mediated nuclear export of HIV RNA pathway
HIV Infection pathway
Influenza Life Cycle pathway
Nuclear import of Rev protein pathway
Metabolism pathway
Host Interactions of HIV factors pathway
Export of Viral Ribonucleoproteins from Nucleus pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Disease pathway
Regulatory RNA pathways pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Sumoylation by ranbp2 regulates transcriptional repression [Biocarta view]
Role of ran in mitotic spindle regulation [Biocarta view]
Mechanism of protein import into the nucleus [Biocarta view]
Cycling of ran in nucleocytoplasmic transport [Biocarta view]
PID NCI
Aurora A signaling
FoxO family signaling
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Canonical NF-kappaB pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.10842 Hs.609092
RefSeq NM_001300796 NM_001300797 NM_006325 XM_005253592
HUGO
OMIM
CCDS CCDS73546 CCDS9271
HPRD 03109
IMGT
EMBL
GenPept
RNA Seq Atlas