Homo sapiens Gene: RAN | |||||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-64798.6 | ||||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||
Gene Symbol | RAN | ||||||||||||||||||||||||||||||||||||||||||
Gene Name | RAN, member RAS oncogene family | ||||||||||||||||||||||||||||||||||||||||||
Synonyms | ARA24; Gsp1; TC4 | ||||||||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000132341 | ||||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
RAN, member RAS oncogene family
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||
Summary |
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy\'s disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy\'s disease. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 12:130871879-130877678 | ||||||||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||
Band | q24.33 | ||||||||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
TCR pathway
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REACTOME |
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Nuclear import of Rev protein pathway
Rev-mediated nuclear export of HIV RNA pathway
NEP/NS2 Interacts with the Cellular Export Machinery pathway
MicroRNA (miRNA) biogenesis pathway
Late Phase of HIV Life Cycle pathway
Influenza Infection pathway
Metabolism of lipids and lipoproteins pathway
Transcriptional regulation by small RNAs pathway
HIV Life Cycle pathway
HIV Infection pathway
Influenza Life Cycle pathway
Metabolism pathway
Host Interactions of HIV factors pathway
Export of Viral Ribonucleoproteins from Nucleus pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Disease pathway
Regulatory RNA pathways pathway
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KEGG |
RNA transport pathway
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INOH | |||||||||||||||||||||||||||||||||||||||||||
PID NCI |
Aurora A signaling
FoxO family signaling
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Canonical NF-kappaB pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Sumoylation by RanBP2 regulates transcriptional repression
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Cross-References | |||||||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||
UniGene | Hs.10842 Hs.609092 | ||||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_001300796 NM_001300797 NM_006325 XM_005253592 | ||||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||||
CCDS | CCDS73546 CCDS9271 | ||||||||||||||||||||||||||||||||||||||||||
HPRD | 03109 | ||||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||