InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MC4R

Summary

InnateDB Gene

IDBG-648013.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC4R

Gene Name

Melanocortin receptor 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019676

Encoded Proteins

IDBP-700783

Melanocortin receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166603:
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:59670136-59671874

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026223

ENSBTAP00000026223

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007631	feeding behavior
GO:0019222	regulation of metabolic process
GO:0030073	insulin secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032868	response to insulin
GO:0045780	positive regulation of bone resorption