Version 5.4
Bos taurus Gene: S1PR4
Summary
InnateDB Gene IDBG-648748.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S1PR4
Gene Name Uncharacterized protein
Synonyms EDG6
Species Bos taurus
Ensembl Gene ENSBTAG00000000381
Encoded Proteins
IDBP-701466
sphingosine-1-phosphate receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125910:
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:21889526-21890683
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000492 ENSBTAP00000000492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000125910
View Gene Order
ENSMUSG00000044199
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18365
Lysosphingolipid and LPA receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_232027
Lysosphingolipid and LPA receptors pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
s1p_meta_pathway
Sphingosine 1-phosphate (S1P) pathway
s1p_s1p4_pathway
S1P4 pathway
Cross-References
SwissProt
TrEMBL F1ME98
UniProt Splice Variant
Entrez Gene 539534
UniGene
RefSeq XM_005198988 XM_005209013
HUGO HGNC:3170
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019662
GenPept
RNA Seq Atlas 539534

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca