Version 5.4
Bos taurus Gene: NGF
Summary
InnateDB Gene IDBG-648895.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NGF
Gene Name Beta-nerve growth factor
Synonyms NGFB
Species Bos taurus
Ensembl Gene ENSBTAG00000007446
Encoded Proteins
IDBP-701600
Beta-nerve growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134259:
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene\'s expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:28124615-28125503
Strand Forward strand
Band
Transcripts
ENSBTAT00000009796 ENSBTAP00000009796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005102 receptor binding
GO:0005163 nerve growth factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0007422 peripheral nervous system development
GO:0007623 circadian rhythm
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0019233 sensory perception of pain
GO:0035556 intracellular signal transduction
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0046928 regulation of neurotransmitter secretion
GO:0048812 neuron projection morphogenesis
GO:0051402 neuron apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134259
View Gene Order
ENSMUSG00000027859
View Gene Order
Pathways
NETPATH
REACTOME
REACT_227719
ARMS-mediated activation pathway
REACT_218381
Signalling to ERKs pathway
REACT_220289
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_204563
p75NTR regulates axonogenesis pathway
REACT_202205
Retrograde neurotrophin signalling pathway
REACT_226916
Activation of TRKA receptors pathway
REACT_206309
NGF processing pathway
REACT_221742
TRKA activation by NGF pathway
REACT_216844
PLC-gamma1 signalling pathway
REACT_219752
Ceramide signalling pathway
REACT_211156
Prolonged ERK activation events pathway
REACT_226623
NRIF signals cell death from the nucleus pathway
REACT_211402
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_214353
Signal Transduction pathway
REACT_214419
Signalling to RAS pathway
REACT_221145
NF-kB is activated and signals survival pathway
REACT_225659
Signalling to p38 via RIT and RIN pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_208369
NRAGE signals death through JNK pathway
REACT_210139
NFG and proNGF binds to p75NTR pathway
REACT_227494
p75NTR recruits signalling complexes pathway
REACT_207066
Signalling by NGF pathway
REACT_224179
NADE modulates death signalling pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
REACT_204115
Signalling to STAT3 pathway
REACT_225332
PI3K/AKT activation pathway
REACT_221826
Axonal growth stimulation pathway
REACT_217712
Frs2-mediated activation pathway
REACT_203904
p75NTR signals via NF-kB pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12464
PI3K/AKT activation pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_11060
TRKA activation by NGF pathway
REACT_13779
Axonal growth stimulation pathway
REACT_13415
p75NTR recruits signalling complexes pathway
REACT_13696
NF-kB is activated and signals survival pathway
REACT_13806
Ceramide signalling pathway
REACT_12049
Signalling to STAT3 pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_11062
NGF processing pathway
REACT_13695
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_13643
NRIF signals cell death from the nucleus pathway
REACT_13526
NADE modulates death signalling pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_13724
NFG and proNGF binds to p75NTR pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_13537
p75NTR signals via NF-kB pathway
REACT_111102
Signal Transduction pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_11064
Activation of TRKA receptors pathway
REACT_205300
PI3K/AKT activation pathway
REACT_222662
p75NTR regulates axonogenesis pathway
REACT_207546
NFG and proNGF binds to p75NTR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_213333
TRKA activation by NGF pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_239722
Signalling to RAS pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_210754
NADE modulates death signalling pathway
REACT_262560
Frs2-mediated activation pathway
REACT_214670
p75NTR recruits signalling complexes pathway
REACT_212952
Signalling to STAT3 pathway
REACT_217312
Ceramide signalling pathway
REACT_231290
Signalling to ERKs pathway
REACT_224536
p75NTR signals via NF-kB pathway
REACT_214242
Axonal growth stimulation pathway
REACT_248921
Signalling by NGF pathway
REACT_218887
NF-kB is activated and signals survival pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_234035
ARMS-mediated activation pathway
REACT_188257
Signal Transduction pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_206713
NGF processing pathway
REACT_202271
NRIF signals cell death from the nucleus pathway
REACT_202086
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_252757
Signalling to p38 via RIT and RIN pathway
REACT_217410
Activation of TRKA receptors pathway
KEGG
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04210
Apoptosis pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt P13600
TrEMBL
UniProt Splice Variant
Entrez Gene 281350
UniGene Bt.12757
RefSeq NM_001099362 XM_005204002
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146037 M26809 Y09566
GenPept AAA30666 AAI46038 CAA70759
RNA Seq Atlas 281350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca