Homo sapiens Gene: RAD51
Summary
InnateDB Gene IDBG-6509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD51
Gene Name RAD51 homolog (S. cerevisiae)
Synonyms BRCC5; HRAD51; HsRad51; HsT16930; MRMV2; RAD51A; RECA;
Species Homo sapiens
Ensembl Gene ENSG00000051180
Encoded Proteins
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
RAD51 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40694774-40732339
Strand Forward strand
Band q15.1
Transcripts
ENST00000382643 ENSP00000372088
ENST00000267868 ENSP00000267868
ENST00000423169 ENSP00000406602
ENST00000527860 ENSP00000432759
ENST00000557850 ENSP00000454176
ENST00000532743 ENSP00000433924
ENST00000525066 ENSP00000431864
ENST00000526763 ENSP00000431897
ENST00000531277 ENSP00000436512
ENST00000533741 ENSP00000433053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 117 [view]
Protein-Protein 112 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0042802 identical protein binding
GO:0043142 single-stranded DNA-dependent ATPase activity
GO:0070182 DNA polymerase binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000730 DNA recombinase assembly
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006312 mitotic recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007126 meiotic nuclear division
GO:0007131 reciprocal meiotic recombination
GO:0009432 SOS response
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0051106 positive regulation of DNA ligation
GO:0051260 protein homooligomerization
GO:0071479 cellular response to ionizing radiation
GO:0072757 cellular response to camptothecin
Cellular Component
GO:0000228 nuclear chromosome
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000800 lateral element
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005815 microtubule organizing center
GO:0016605 PML body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Homologous Recombination Repair pathway
Double-Strand Break Repair pathway
Cell Cycle pathway
Meiotic recombination pathway
Homologous DNA pairing and strand exchange pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Meiosis pathway
Presynaptic phase of homologous DNA pairing and strand exchange pathway
DNA Repair pathway
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
KEGG
Homologous recombination pathway
Pathways in cancer pathway
Pancreatic cancer pathway
INOH
PID BIOCARTA
Atm signaling pathway [Biocarta view]
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
PID NCI
p73 transcription factor network
BARD1 signaling events
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.607865
RefSeq NM_001164269 NM_001164270 NM_002875 NM_133487 XM_006720626
HUGO
OMIM
CCDS CCDS10062 CCDS53931 CCDS53932
HPRD 01557
IMGT
EMBL
GenPept
RNA Seq Atlas