Homo sapiens Gene: PRKCA
Summary
InnateDB Gene IDBG-65194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKCA
Gene Name protein kinase C, alpha
Synonyms AAG6; PKC-alpha; PKCA; PRKACA;
Species Homo sapiens
Ensembl Gene ENSG00000154229
Encoded Proteins
protein kinase C, alpha
protein kinase C, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PRKCA is a key component that controls MyD88-dependent cytokine gene expression in human and mouse but differentially regulates production of TICAM1 (TRIF)-dependent cytokines.
Entrez Gene
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:66302636-66810743
Strand Forward strand
Band q24.2
Transcripts
ENST00000284384 ENSP00000284384
ENST00000413366 ENSP00000408695
ENST00000583775
ENST00000583361
ENST00000578063 ENSP00000462087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 148 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 148 [view]
Protein-Protein 148 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0035403 histone kinase activity (H3-T6 specific)
GO:0046872 metal ion binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002026 regulation of the force of heart contraction
GO:0002062 chondrocyte differentiation
GO:0002159 desmosome assembly
GO:0006112 energy reserve metabolic process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006874 cellular calcium ion homeostasis
GO:0006937 regulation of muscle contraction
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0007603 phototransduction, visible light
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016056 rhodopsin mediated signaling pathway
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035408 histone H3-T6 phosphorylation
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045651 positive regulation of macrophage differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045931 positive regulation of mitotic cell cycle
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050796 regulation of insulin secretion
GO:0050930 induction of positive chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070555 response to interleukin-1
GO:0071322 cellular response to carbohydrate stimulus
GO:0090330 regulation of platelet aggregation
GO:0097190 apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:2000707 positive regulation of dense core granule biogenesis
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0031966 mitochondrial membrane
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
Wnt pathway
TNFalpha pathway
IL3 pathway
TSH pathway
IL11 pathway
REACTOME
Signaling by FGFR in disease pathway
PCP/CE pathway pathway
Integration of energy metabolism pathway
CaM pathway pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Phospholipase C-mediated cascade pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Extracellular matrix organization pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
Syndecan interactions pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
PLC-gamma1 signalling pathway
Opioid Signalling pathway
HuR stabilizes mRNA pathway
DAG and IP3 signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Acetylcholine regulates insulin secretion pathway
G-protein mediated events pathway
Cell Cycle pathway
Diseases associated with visual transduction pathway
Immune System pathway
Trafficking of AMPA receptors pathway
Downstream signal transduction pathway
VEGFR2 mediated cell proliferation pathway
Non-integrin membrane-ECM interactions pathway
G alpha (z) signalling events pathway
Disinhibition of SNARE formation pathway
M Phase pathway
VEGFA-VEGFR2 Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
NGF signalling via TRKA from the plasma membrane pathway
Mitotic Prophase pathway
Visual phototransduction pathway
Transmission across Chemical Synapses pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Cell Cycle, Mitotic pathway
EGFR Transactivation by Gastrin pathway
Signaling by FGFR pathway
The phototransduction cascade pathway
Regulation of insulin secretion pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Regulation of KIT signaling pathway
Metabolism pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
PLCG1 events in ERBB2 signaling pathway
Trafficking of GluR2-containing AMPA receptors pathway
Depolymerisation of the Nuclear Lamina pathway
Ca-dependent events pathway
Calmodulin induced events pathway
Gene Expression pathway
Nuclear Envelope Breakdown pathway
Disease pathway
Hemostasis pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Long-term potentiation pathway
Long-term depression pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Aldosterone-regulated sodium reabsorption pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Vibrio cholerae infection pathway
Pathogenic Escherichia coli infection pathway
African trypanosomiasis pathway
Amoebiasis pathway
Pathways in cancer pathway
Glioma pathway
Non-small cell lung cancer pathway
INOH
GPCR signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Ionomycin and phorbal ester signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Attenuation of gpcr signaling [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Telomeres telomerase cellular aging and immortality [Biocarta view]
Bcr signaling pathway [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
G-secretase mediated erbb4 signaling pathway [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
Regulation of eif-4e and p70s6 kinase [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Nitric oxide signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
Activation of pkc through g-protein coupled receptors [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
Downstream signaling in na´ve CD8+ T cells
PAR1-mediated thrombin signaling events
ErbB1 downstream signaling
mTOR signaling pathway
a6b1 and a6b4 Integrin signaling
ATF-2 transcription factor network
Retinoic acid receptors-mediated signaling
Ras signaling in the CD4+ TCR pathway
Canonical NF-kappaB pathway
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Signaling events regulated by Ret tyrosine kinase
VEGFR1 specific signals
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.531704 Hs.611592 Hs.708867
RefSeq NM_002737
HUGO
OMIM
CCDS CCDS11664
HPRD 01498
IMGT
EMBL
GenPept
RNA Seq Atlas