Homo sapiens Gene: KLK7
Summary
InnateDB Gene IDBG-65268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK7
Gene Name kallikrein-related peptidase 7
Synonyms hK7; PRSS6; SCCE;
Species Homo sapiens
Ensembl Gene ENSG00000169035
Encoded Proteins
kallikrein-related peptidase 7
kallikrein-related peptidase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50976482-50984099
Strand Reverse strand
Band q13.41
Transcripts
ENST00000304045 ENSP00000304791
ENST00000391807 ENSP00000375683
ENST00000595820 ENSP00000470538
ENST00000597707 ENSP00000469950
ENST00000593904 ENSP00000470084
ENST00000595638
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008544 epidermis development
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0097209 epidermal lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.151254
RefSeq NM_001207053 NM_001243126 NM_005046 NM_139277
HUGO
OMIM
CCDS CCDS12812 CCDS59414
HPRD 05115
IMGT
EMBL
GenPept
RNA Seq Atlas