Homo sapiens Gene: GNG2
Summary
InnateDB Gene IDBG-6595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNG2
Gene Name guanine nucleotide binding protein (G protein), gamma 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186469
Encoded Proteins
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), gamma 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:51826195-51979342
Strand Forward strand
Band q22.1
Transcripts
ENST00000335281 ENSP00000334448
ENST00000553432 ENSP00000451279
ENST00000556522 ENSP00000450904
ENST00000557376 ENSP00000450758
ENST00000553560 ENSP00000450586
ENST00000554832
ENST00000553299
ENST00000557208
ENST00000555472 ENSP00000451102
ENST00000556766 ENSP00000451231
ENST00000554840
ENST00000554736 ENSP00000452014
ENST00000556752 ENSP00000451576
ENST00000556471
ENST00000554875 ENSP00000451536
ENST00000615906 ENSP00000484021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0030168 platelet activation
GO:0044281 small molecule metabolic process
GO:0071377 cellular response to glucagon stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071870 cellular response to catecholamine stimulus
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
ADP signalling through P2Y purinoceptor 12 pathway
Presynaptic function of Kainate receptors pathway
Transmembrane transport of small molecules pathway
G alpha (12/13) signalling events pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
beta-catenin independent WNT signaling pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Prostacyclin signalling through prostacyclin receptor pathway
GABA receptor activation pathway
Glucagon signaling in metabolic regulation pathway
G protein gated Potassium channels pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Glucagon-type ligand receptors pathway
G-protein activation pathway
Inwardly rectifying K+ channels pathway
Activation of Kainate Receptors upon glutamate binding pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Platelet homeostasis pathway
G alpha (z) signalling events pathway
Potassium Channels pathway
GABA B receptor activation pathway
Thromboxane signalling through TP receptor pathway
Transmission across Chemical Synapses pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
ADP signalling through P2Y purinoceptor 1 pathway
G beta:gamma signalling through PLC beta pathway
GPCR ligand binding pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Signal amplification pathway
Activation of G protein gated Potassium channels pathway
Class B/2 (Secretin family receptors) pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Nongenotropic Androgen signaling
Rapid glucocorticoid signaling
Thromboxane A2 receptor signaling
IL8- and CXCR2-mediated signaling events
LPA receptor mediated events
CXCR4-mediated signaling events
IL8- and CXCR1-mediated signaling events
PAR1-mediated thrombin signaling events
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
PAR4-mediated thrombin signaling events
Hedgehog signaling events mediated by Gli proteins
CXCR3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.187772 Hs.709082 Hs.720063 Hs.741081
RefSeq NM_001243773 NM_001243774 NM_053064 XM_006720173
HUGO
OMIM
CCDS CCDS32082
HPRD 16234
IMGT
EMBL
GenPept
RNA Seq Atlas