Homo sapiens Gene: GAB2
Summary
InnateDB Gene IDBG-65975.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAB2
Gene Name GRB2-associated binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000033327
Encoded Proteins
GRB2-associated binding protein 2
GRB2-associated binding protein 2
GRB2-associated binding protein 2
GRB2-associated binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:78215297-78418348
Strand Reverse strand
Band q14.1
Transcripts
ENST00000361507 ENSP00000354952
ENST00000340149 ENSP00000343959
ENST00000528329
ENST00000526030
ENST00000528886 ENSP00000433762
ENST00000530915 ENSP00000431868
ENST00000534823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 49 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0009967 positive regulation of signal transduction
GO:0030316 osteoclast differentiation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043306 positive regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
RANKL pathway
TSLP pathway
Prolactin pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
Hemostasis pathway
KEGG
Osteoclast differentiation pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Chronic myeloid leukemia pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Neurotrophic factor-mediated Trk receptor signaling
IL3-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.429434 Hs.695032
RefSeq NM_012296 NM_080491 XM_006718753
HUGO
OMIM
CCDS CCDS8259 CCDS8260
HPRD 05866
IMGT
EMBL
GenPept
RNA Seq Atlas