Version 5.4
Homo sapiens Gene: SIGLEC6
Summary
InnateDB Gene IDBG-66055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC6
Gene Name sialic acid binding Ig-like lectin 6
Synonyms CD327; CD33L; CD33L1; CD33L2; CDW327; OBBP1
Species Homo sapiens
Ensembl Gene ENSG00000105492
Encoded Proteins
IDBP-66057
sialic acid binding Ig-like lectin 6
IDBP-66059
sialic acid binding Ig-like lectin 6
IDBP-66061
sialic acid binding Ig-like lectin 6
IDBP-246968
sialic acid binding Ig-like lectin 6
IDBP-384156
sialic acid binding Ig-like lectin 6
IDBP-384158
sialic acid binding Ig-like lectin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC6 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51519525-51531856
Strand Reverse strand
Band q13.41
Transcripts
ENST00000343300 ENSP00000345907
ENST00000359982 ENSP00000353071
ENST00000346477 ENSP00000344064
ENST00000391797 ENSP00000375674
ENST00000425629 ENSP00000401502
ENST00000436458 ENSP00000410679
ENST00000474054
ENST00000496422
ENST00000489837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007267 cell-cell signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.720304
RefSeq NM_001177547 NM_001177548 NM_001177549 NM_001245 NM_198845 NM_198846
HUGO
OMIM
CCDS CCDS12834 CCDS12835 CCDS12836 CCDS54307 CCDS54308 CCDS59417
HPRD 16058
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca