Homo sapiens Gene: HIST1H2AA
Summary
InnateDB Gene IDBG-66276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST1H2AA
Gene Name histone cluster 1, H2aa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164508
Encoded Proteins
histone cluster 1, H2aa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:25726132-25726527
Strand Reverse strand
Band p22.2
Transcripts
ENST00000297012 ENSP00000297012
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
KEGG
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96QV6
TrEMBL
UniProt Splice Variant
Entrez Gene 221613
UniGene Hs.406739
RefSeq NM_170745
HUGO HGNC:18729
OMIM 613499
CCDS CCDS4562
HPRD 13653
IMGT
EMBL AL512384 AY131982 BC062211
GenPept AAH62211 AAN59963 CAC44614
RNA Seq Atlas 221613