Version 5.4
Homo sapiens Gene: NID2
Summary
InnateDB Gene IDBG-6648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NID2
Gene Name nidogen 2 (osteonidogen)
Synonyms NID-2
Species Homo sapiens
Ensembl Gene ENSG00000087303
Encoded Proteins
IDBP-6650
nidogen 2 (osteonidogen)
IDBP-603510
nidogen 2 (osteonidogen)
IDBP-599763
nidogen 2 (osteonidogen)
IDBP-807996
nidogen 2 (osteonidogen)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:52004803-52069228
Strand Reverse strand
Band q22.1
Transcripts
ENST00000216286 ENSP00000216286
ENST00000556686
ENST00000555310
ENST00000556572 ENSP00000452190
ENST00000553297
ENST00000557051
ENST00000554284
ENST00000541773 ENSP00000443730
ENST00000617139 ENSP00000482803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0030198 extracellular matrix organization
GO:0071711 basement membrane organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021806
View Gene Order
ENSBTAG00000021945
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_169262
Laminin interactions pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 22795
UniGene
RefSeq NM_007361
HUGO HGNC:13389
OMIM 605399
CCDS CCDS9706
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 22795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca