Homo sapiens Gene: PPP2R1A
Summary
InnateDB Gene IDBG-66700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R1A
Gene Name protein phosphatase 2, regulatory subunit A, alpha
Synonyms PP2A-Aalpha; PP2AAALPHA; PR65A;
Species Homo sapiens
Ensembl Gene ENSG00000105568
Encoded Proteins
protein phosphatase 2, regulatory subunit A, alpha
protein phosphatase 2, regulatory subunit A, alpha
protein phosphatase 2, regulatory subunit A, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:52190039-52229533
Strand Forward strand
Band q13.41
Transcripts
ENST00000322088 ENSP00000324804
ENST00000391791 ENSP00000375668
ENST00000454220 ENSP00000391905
ENST00000490868 ENSP00000469150
ENST00000477989 ENSP00000471298
ENST00000468280
ENST00000462990 ENSP00000470504
ENST00000495876
ENST00000473455
ENST00000462047
ENST00000473820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 228 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 228 [view]
Protein-Protein 227 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004722 protein serine/threonine phosphatase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 inactivation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0006275 regulation of DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0006470 protein dephosphorylation
GO:0006672 ceramide metabolic process
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007084 mitotic nuclear envelope reassembly
GO:0008380 RNA splicing
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019932 second-messenger-mediated signaling
GO:0030111 regulation of Wnt signaling pathway
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0040008 regulation of growth
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595 regulation of cell differentiation
GO:0070262 peptidyl-serine dephosphorylation
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Cyclin A/B1 associated events during G2/M transition pathway
Signaling by FGFR in disease pathway
Integration of energy metabolism pathway
truncated APC mutants destabilize the destruction complex pathway
G1 Phase pathway
MyD88 dependent cascade initiated on endosome pathway
Beta-catenin phosphorylation cascade pathway
Signalling by NGF pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Nonsense-Mediated Decay (NMD) pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Signaling by WNT in cancer pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Myoclonic epilepsy of Lafora pathway
AXIN missense mutants destabilize the destruction complex pathway
Initiation of Nuclear Envelope Reformation pathway
Signaling by Wnt pathway
Loss of Nlp from mitotic centrosomes pathway
MyD88 cascade initiated on plasma membrane pathway
Mitotic G1-G1/S phases pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
ERKs are inactivated pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
APC truncation mutants have impaired AXIN binding pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Cyclin D associated events in G1 pathway
Toll-Like Receptors Cascades pathway
Spry regulation of FGF signaling pathway
Degradation of beta-catenin by the destruction complex pathway
Opioid Signalling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
G1/S Transition pathway
Signal Transduction pathway
Separation of Sister Chromatids pathway
MAP kinase activation in TLR cascade pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Regulation of PLK1 Activity at G2/M Transition pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Adaptive Immune System pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Platelet homeostasis pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Centrosome maturation pathway
PP2A-mediated dephosphorylation of key metabolic factors pathway
TCF dependent signaling in response to WNT pathway
E2F mediated regulation of DNA replication pathway
NGF signalling via TRKA from the plasma membrane pathway
G2/M Transition pathway
Mitotic Prophase pathway
Nuclear Envelope Reassembly pathway
Glycolysis pathway
MASTL Facilitates Mitotic Progression pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
Signaling by FGFR pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Mitotic G2-G2/M phases pathway
Metabolism pathway
Negative regulation of FGFR signaling pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
DARPP-32 events pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Costimulation by the CD28 family pathway
Platelet sensitization by LDL pathway
CTLA4 inhibitory signaling pathway
Resolution of Sister Chromatid Cohesion pathway
ERK/MAPK targets pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
Mitotic Metaphase and Anaphase pathway
KEGG
mRNA surveillance pathway pathway
Oocyte meiosis pathway
TGF-beta signaling pathway pathway
Tight junction pathway
Long-term depression pathway
Chagas disease (American trypanosomiasis) pathway
Hepatitis C pathway
INOH
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
IL8- and CXCR2-mediated signaling events
ErbB1 downstream signaling
ATR signaling pathway
PDGFR-beta signaling pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467192 Hs.612960
RefSeq NM_014225
HUGO
OMIM
CCDS CCDS12849
HPRD 16184
IMGT
EMBL
GenPept
RNA Seq Atlas