Version 5.4
Homo sapiens Gene: BMP15
Summary
InnateDB Gene IDBG-67313.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP15
Gene Name bone morphogenetic protein 15
Synonyms GDF9B; ODG2; POF4
Species Homo sapiens
Ensembl Gene ENSG00000130385
Encoded Proteins
IDBP-67315
bone morphogenetic protein 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:50910784-50916607
Strand Forward strand
Band p11.22
Transcripts
ENST00000252677 ENSP00000252677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
Biological Process
GO:0001541 ovarian follicle development
GO:0007292 female gamete generation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060016 granulosa cell development
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023279
View Gene Order
ENSBTAG00000045782
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt O95972
TrEMBL
UniProt Splice Variant
Entrez Gene 9210
UniGene Hs.532692
RefSeq NM_005448
HUGO HGNC:1068
OMIM 300247
CCDS CCDS14334
HPRD
IMGT
EMBL AF082349 AF082350 AJ132405 AL359914 BC069155 BC117264 BC117266
GenPept AAC99768 AAH69155 AAI17265 AAI17267 CAB43531 CAI41226
RNA Seq Atlas 9210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca