Homo sapiens Gene: CHMP4B
Summary
InnateDB Gene IDBG-67444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP4B
Gene Name charged multivesicular body protein 4B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101421
Encoded Proteins
charged multivesicular body protein 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:33811304-33854366
Strand Forward strand
Band q11.22
Transcripts
ENST00000217402 ENSP00000217402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006620 posttranslational protein targeting to membrane
GO:0007034 vacuolar transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0050792 regulation of viral process
GO:0051260 protein homooligomerization
GO:0061024 membrane organization
GO:1901215 negative regulation of neuron death
GO:1902188 positive regulation of viral release from host cell
GO:1902902 negative regulation of autophagic vacuole assembly
Cellular Component
GO:0000815 ESCRT III complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Budding and maturation of HIV virion pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H444
TrEMBL
UniProt Splice Variant
Entrez Gene 128866
UniGene
RefSeq NM_176812
HUGO HGNC:16171
OMIM 610897
CCDS CCDS13228
HPRD
IMGT
EMBL AB100261 AL050349 AY329085 BC033859 CH471077
GenPept AAH33859 AAQ91194 BAC79375 CAC14088 EAW76293 EAW76294
RNA Seq Atlas 128866