InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHMP4B

Summary

InnateDB Gene

IDBG-67444.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHMP4B

Gene Name

charged multivesicular body protein 4B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000101421

Encoded Proteins

IDBP-67446

charged multivesicular body protein 4B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:33811304-33854366

Strand

Forward strand

Band

q11.22

Transcripts

ENST00000217402

ENSP00000217402

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006620	posttranslational protein targeting to membrane
GO:0007034	vacuolar transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0050792	regulation of viral process
GO:0051260	protein homooligomerization
GO:0061024	membrane organization
GO:1901215	negative regulation of neuron death
GO:1902188	positive regulation of viral release from host cell
GO:1902902	negative regulation of autophagic vacuole assembly

Cellular Component

GO:0000815	ESCRT III complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009898	cytoplasmic side of plasma membrane
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038467

View Gene Order

ENSBTAG00000013387

Not yet available

Pathways

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_176812

HUGO

OMIM

CCDS

CCDS13228

HPRD

16642

IMGT

EMBL

GenPept

RNA Seq Atlas