Homo sapiens Gene: AP2M1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-67524.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | AP2M1 | ||||||||||||||||||||||||||
Gene Name | adaptor-related protein complex 2, mu 1 subunit | ||||||||||||||||||||||||||
Synonyms | AP50; CLAPM1; mu2 | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Gene | ENSG00000161203 | ||||||||||||||||||||||||||
Encoded Proteins |
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
adaptor-related protein complex 2, mu 1 subunit
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 3:184174689-184184091 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | q27.1 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
MHC class II antigen presentation pathway
Retrograde neurotrophin signalling pathway
EGFR downregulation pathway
Signaling by EGFR pathway
Nef Mediated CD8 Down-regulation pathway
Nef Mediated CD4 Down-regulation pathway
Nef mediated downregulation of CD28 cell surface expression pathway
Formation of annular gap junctions pathway
Gap junction degradation pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
PCP/CE pathway pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Axon guidance pathway
Signal Transduction pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Gap junction trafficking pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
EPH-ephrin mediated repulsion of cells pathway
HIV Infection pathway
EPH-Ephrin signaling pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Gap junction trafficking and regulation pathway
Disease pathway
Membrane Trafficking pathway
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KEGG |
Endocytosis pathway
Huntington's disease pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
Arf1 pathway
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Hs.518460 Hs.713745 | ||||||||||||||||||||||||||
RefSeq | NM_001025205 NM_004068 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS43177 CCDS43178 | ||||||||||||||||||||||||||
HPRD | 03014 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||