Homo sapiens Gene: DBI
Summary
InnateDB Gene IDBG-67980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBI
Gene Name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Synonyms ACBD1; ACBP; CCK-RP; EP;
Species Homo sapiens
Ensembl Gene ENSG00000155368
Encoded Proteins
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119366921-119372560
Strand Forward strand
Band q14.2
Transcripts
ENST00000355857 ENSP00000348116
ENST00000311521 ENSP00000311117
ENST00000393103 ENSP00000376815
ENST00000409094 ENSP00000386486
ENST00000492375
ENST00000460901
ENST00000475783
ENST00000535617 ENSP00000442917
ENST00000542275 ENSP00000440698
ENST00000535757 ENSP00000439012
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0008289 lipid binding
GO:0030156 benzodiazepine receptor binding
GO:0036042 long-chain fatty acyl-CoA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001942 hair follicle development
GO:0006641 triglyceride metabolic process
GO:0006810 transport
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0043588 skin development
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
PPAR signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P07108
TrEMBL A0A024RAF2 B8ZWD8
UniProt Splice Variant
Entrez Gene 1622
UniGene
RefSeq NM_001079862 NM_001282635 NM_001079863 NM_020548 NM_001178042 NM_001282634 NM_001282633 NM_001178043
HUGO HGNC:2690
OMIM 125950
CCDS CCDS2126 CCDS42740 CCDS42741 CCDS74568
HPRD 08832
IMGT
EMBL AC016736 AM000001 BC006466 BC062996 CH471103 CR456956 FM213123 FM213124 FM213125 FM213126 FM213127 FM213128 FM213129 FM213131 M14200 M15887
GenPept AAA35788 AAA52171 AAH62996 AAY14873 CAG33237 CAJ00736 CAR82405 CAR82406 CAR82407 CAR82408 CAR82409 CAR82410 CAR82411 CAR82414 EAW95214 EAW95215 EAW95216
RNA Seq Atlas 1622