Homo sapiens Gene: MED17
Summary
InnateDB Gene IDBG-68107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED17
Gene Name mediator complex subunit 17
Synonyms CRSP6; CRSP77; DRIP80; TRAP80;
Species Homo sapiens
Ensembl Gene ENSG00000042429
Encoded Proteins
mediator complex subunit 17
mediator complex subunit 17
mediator complex subunit 17
mediator complex subunit 17
mediator complex subunit 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:93784227-93814695
Strand Forward strand
Band q21
Transcripts
ENST00000251871 ENSP00000251871
ENST00000507258
ENST00000530819 ENSP00000434459
ENST00000533359 ENSP00000431524
ENST00000533133 ENSP00000433090
ENST00000528786 ENSP00000433626
ENST00000525026
ENST00000533367
ENST00000531920
ENST00000525613
ENST00000529626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 85 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004872 receptor activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0019827 stem cell maintenance
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0016020 membrane
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Generic Transcription Pathway pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444931
RefSeq NM_004268
HUGO
OMIM
CCDS CCDS8295
HPRD 04816
IMGT
EMBL
GenPept
RNA Seq Atlas