Homo sapiens Gene: GRB2
Summary
InnateDB Gene IDBG-68262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB2
Gene Name growth factor receptor-bound protein 2
Synonyms ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2;
Species Homo sapiens
Ensembl Gene ENSG00000177885
Encoded Proteins
growth factor receptor-bound protein 2
growth factor receptor-bound protein 2
growth factor receptor-bound protein 2
growth factor receptor-bound protein 2
growth factor receptor-bound protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75318076-75405709
Strand Reverse strand
Band q25.1
Transcripts
ENST00000316804 ENSP00000339007
ENST00000316615 ENSP00000317360
ENST00000392564 ENSP00000376347
ENST00000392563 ENSP00000376346
ENST00000392562 ENSP00000376345
ENST00000462266
ENST00000581959 ENSP00000463525
ENST00000583912
ENST00000582582 ENSP00000462785
ENST00000578961 ENSP00000464279
ENST00000577711
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 663 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Experimentally validated
Total 663 [view]
Protein-Protein 660 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043560 insulin receptor substrate binding
GO:0044822 poly(A) RNA binding
GO:0046875 ephrin receptor binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0007568 aging
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0016032 viral process
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031623 receptor internalization
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042770 signal transduction in response to DNA damage
GO:0043408 regulation of MAPK cascade
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050900 leukocyte migration
GO:0051291 protein heterooligomerization
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0071479 cellular response to ionizing radiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0070436 Grb2-EGFR complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL9 pathway
Leptin pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Dorso-ventral axis formation pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Gap junction pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Hepatitis C pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Inhibition of cellular proliferation by gleevec [Biocarta view]
Il 2 signaling pathway [Biocarta view]
Il 3 signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Il 6 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
The co-stimulatory signal during t-cell activation [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Epo signaling pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Integrin signaling pathway [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Insulin signaling pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
TCR signaling in na´ve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
ErbB4 signaling events
TCR signaling in na´ve CD4+ T cells
Internalization of ErbB1
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
ErbB1 downstream signaling
a6b1 and a6b4 Integrin signaling
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPO signaling pathway
EPHB forward signaling
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
Regulation of Ras family activation
IL4-mediated signaling events
ErbB2/ErbB3 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
IL3-mediated signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
TGF-beta receptor signaling
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
PDGFR-alpha signaling pathway
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
IL6-mediated signaling events
Insulin Pathway
IL5-mediated signaling events
Cross-References
SwissProt
TrEMBL J3QRL5
UniProt Splice Variant
Entrez Gene 2885
UniGene Hs.444356
RefSeq NM_002086 NM_203506
HUGO HGNC:4566
OMIM 108355
CCDS CCDS11721 CCDS11722
HPRD 00150
IMGT
EMBL AC011933
GenPept
RNA Seq Atlas 2885