Homo sapiens Gene: YAP1
Summary
InnateDB Gene IDBG-68995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YAP1
Gene Name Yes-associated protein 1
Synonyms COB1; YAP; YAP2; YAP65; YKI;
Species Homo sapiens
Ensembl Gene ENSG00000137693
Encoded Proteins
Yes-associated protein 1
Yes-associated protein 1
Yes-associated protein 1
Yes-associated protein 1
Yes-associated protein 1
Yes-associated protein 1
Yes-associated protein 1
Yes-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008]
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102110461-102233423
Strand Forward strand
Band q22.1
Transcripts
ENST00000282441 ENSP00000282441
ENST00000345877 ENSP00000331023
ENST00000526343 ENSP00000434134
ENST00000531439 ENSP00000431574
ENST00000524575 ENSP00000435602
ENST00000526594
ENST00000529029 ENSP00000431626
ENST00000528834
ENST00000537274 ENSP00000445635
ENST00000615667 ENSP00000478927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 158 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0070064 proline-rich region binding
Biological Process
GO:0001570 vasculogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0010837 regulation of keratinocyte proliferation
GO:0030216 keratinocyte differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030903 notochord development
GO:0035019 somatic stem cell maintenance
GO:0035329 hippo signaling
GO:0042127 regulation of cell proliferation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046622 positive regulation of organ growth
GO:0048339 paraxial mesoderm development
GO:0048368 lateral mesoderm development
GO:0060242 contact inhibition
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0071480 cellular response to gamma radiation
GO:0072091 regulation of stem cell proliferation
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
Signaling by ERBB4 pathway
Signaling by Hippo pathway
PPARA activates gene expression pathway
Signal Transduction pathway
Generic Transcription Pathway pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Nuclear signaling by ERBB4 pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
ErbB4 signaling events
p73 transcription factor network
TGF-beta receptor signaling
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt P46937
TrEMBL
UniProt Splice Variant
Entrez Gene 10413
UniGene Hs.503692 Hs.701057 Hs.737025
RefSeq NM_001282100 XM_005271381 XM_005271383 NM_001130145 NM_006106 NM_001282098 NM_001195044 NM_001195045 NM_001282101 NM_001282097 NM_001282099 XM_005271380 XM_005271378
HUGO HGNC:16262
OMIM 606608
CCDS CCDS60944 CCDS44716 CCDS8314 CCDS53699 CCDS53700 CCDS73373 CCDS73374
HPRD 09424
IMGT
EMBL AB567720 AB567721 AK300414 AK316116 AP000942 AP001527 AP002777 AY316529 BC038235 CH471065 HE864159 HE864160 HE864161 HE864162 X80507
GenPept AAH38235 AAP92710 BAG62143 BAH14487 BAJ41471 BAJ41472 CAA56672 CCI79618 CCI79619 CCI79620 CCI79621 EAW67011 EAW67015
RNA Seq Atlas 10413