InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YAP1

Summary

InnateDB Gene

IDBG-68995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YAP1

Gene Name

Yes-associated protein 1

Synonyms

COB1; YAP; YAP2; YAP65; YKI

Species

Homo sapiens

Ensembl Gene

ENSG00000137693

Encoded Proteins

IDBP-68997

Yes-associated protein 1

IDBP-68999

Yes-associated protein 1

IDBP-590100

Yes-associated protein 1

IDBP-584021

Yes-associated protein 1

IDBP-599002

Yes-associated protein 1

IDBP-588619

Yes-associated protein 1

IDBP-593201

Yes-associated protein 1

IDBP-810901

Yes-associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008]
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102110461-102233423

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000282441	ENSP00000282441
ENST00000345877	ENSP00000331023
ENST00000526343	ENSP00000434134
ENST00000531439	ENSP00000431574
ENST00000524575	ENSP00000435602
ENST00000526594
ENST00000529029	ENSP00000431626
ENST00000528834
ENST00000537274	ENSP00000445635
ENST00000615667	ENSP00000478927

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	158 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0070064	proline-rich region binding

Biological Process

GO:0001570	vasculogenesis
GO:0003143	embryonic heart tube morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010467	gene expression
GO:0010837	regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030903	notochord development
GO:0035019	somatic stem cell maintenance
GO:0035329	hippo signaling
GO:0042127	regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046622	positive regulation of organ growth
GO:0048339	paraxial mesoderm development
GO:0048368	lateral mesoderm development
GO:0060242	contact inhibition
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071480	cellular response to gamma radiation
GO:0072091	regulation of stem cell proliferation
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053110

View Gene Order

ENSBTAG00000039307

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_116022

Nuclear signaling by ERBB4 pathway

REACT_115596

Signaling by ERBB4 pathway

REACT_118607

Signaling by Hippo pathway

REACT_116145

PPARA activates gene expression pathway

REACT_19241

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_118713

YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111102

Signal Transduction pathway

REACT_111217

Metabolism pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

erbb4_pathway

ErbB4 signaling events

p73pathway

p73 transcription factor network

tgfbrpathway

TGF-beta receptor signaling

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

P46937

TrEMBL

A0A024R3E4 K0KVU2

UniProt Splice Variant

Entrez Gene

10413

UniGene

Hs.503692 Hs.701057 Hs.737025

RefSeq

NM_001130145 NM_001195044 NM_001195045 NM_001282097 NM_001282098 NM_001282099 NM_001282100 NM_001282101 NM_006106 XM_005271378 XM_005271380 XM_005271381 XM_005271383

HUGO

HGNC:16262

OMIM

606608

CCDS

CCDS44716 CCDS53699 CCDS53700 CCDS60944 CCDS73373 CCDS73374 CCDS8314

HPRD

IMGT

EMBL

AB567720 AB567721 AK300414 AK316116 AP000942 AP001527 AP002777 AY316529 BC038235 CH471065 HE864159 HE864160 HE864161 HE864162 HE864163 X80507

GenPept

AAH38235 AAP92710 BAG62143 BAH14487 BAJ41471 BAJ41472 CAA56672 CCI79618 CCI79619 CCI79620 CCI79621 CCI79622 EAW67011 EAW67012 EAW67014 EAW67015

RNA Seq Atlas

10413