Homo sapiens Gene: PARD3
Summary
InnateDB Gene IDBG-69007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARD3
Gene Name par-3 partitioning defective 3 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148498
Encoded Proteins
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
par-3 partitioning defective 3 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Atypical PKC and PARD3 are inhibitors of the canonical NF-κB activation pathway in epithelial cells.
Entrez Gene
Summary This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:34109560-34815325
Strand Reverse strand
Band p11.21
Transcripts
ENST00000374789 ENSP00000363921
ENST00000374788 ENSP00000363920
ENST00000346874 ENSP00000340591
ENST00000350537 ENSP00000311986
ENST00000374790 ENSP00000363922
ENST00000374794 ENSP00000363926
ENST00000374776 ENSP00000363908
ENST00000374773 ENSP00000363905
ENST00000340077 ENSP00000341844
ENST00000374768 ENSP00000363900
ENST00000466092
ENST00000545693 ENSP00000443147
ENST00000545260 ENSP00000440857
ENST00000544292 ENSP00000444429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 87 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0019903 protein phosphatase binding
GO:0032266 phosphatidylinositol-3-phosphate binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0003383 apical constriction
GO:0006461 protein complex assembly
GO:0006612 protein targeting to membrane
GO:0007049 cell cycle
GO:0007163 establishment or maintenance of cell polarity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0008356 asymmetric cell division
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0022011 myelination in peripheral nervous system
GO:0031643 positive regulation of myelination
GO:0032970 regulation of actin filament-based process
GO:0034329 cell junction assembly
GO:0044319 wound healing, spreading of cells
GO:0045087 innate immune response (InnateDB)
GO:0045216 cell-cell junction organization
GO:0051642 centrosome localization
GO:0060341 regulation of cellular localization
GO:0070830 tight junction assembly
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0012505 endomembrane system
GO:0030054 cell junction
GO:0033269 internode region of axon
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0044295 axonal growth cone
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
TCR pathway
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Tight junction interactions pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Cell-Cell communication pathway
Cell junction organization pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell-cell junction organization pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Chemokine signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Endocytosis pathway
Adherens junction pathway
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8TEW0
TrEMBL
UniProt Splice Variant
Entrez Gene 56288
UniGene Hs.131489 Hs.618469
RefSeq NM_001184785 XM_005252528 XM_006717471 XM_006717473 XM_006717476 XM_006717477 NM_001184786 NM_001184787 NM_001184788 NM_001184789 NM_001184790 NM_001184791 NM_001184792 NM_001184793 NM_001184794 NM_019619 XM_005252534 XM_005252535 XM_006717472 XM_006717474 XM_006717475 XM_006717478
HUGO HGNC:16051
OMIM 606745
CCDS CCDS53515 CCDS53509 CCDS53510 CCDS53511 CCDS53512 CCDS53513 CCDS53514 CCDS53516 CCDS7178
HPRD 05994
IMGT
EMBL AB073671 AF177228 AF196185 AF196186 AF252293 AF332592 AF332593 AF467002 AF467003 AF467004 AF467005 AF467006 AK000761 AK027735 AL138768 AL160409 AL360233 AL390766 AL392123 AL450337 BC011711 BC071566 CH471072
GenPept AAF71530 AAG33676 AAH11711 AAH71566 AAK27891 AAK27892 AAK69192 AAK69193 AAL76042 AAL76043 AAL76044 AAL76045 AAL76046 BAA91366 BAB55330 BAC54037 CAH71161 CAH71162 CAH71163 CAH71165 CAH71166 CAH71167 CAH73524 CAH73525 CAH73526 CAH73528 CAH73529 CAI15036 CAI15037 CAI15038 CAI15039 CAI15040 CAI15041 CAI16985 CAI16986 CAI16987 CAI16988 CAI16989 CAI16991 CAI17304 CAI17305 CAI17306 CAI17308 CAI17309 CAI17310 CAI17327 CAI17328 CAI17329 CAI17331 CAI17332 CAI17333 EAW85932 EAW85934
RNA Seq Atlas 56288