Homo sapiens Gene: TJP2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-69307.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | TJP2 | ||||||||||||||||||||||
Gene Name | tight junction protein 2 | ||||||||||||||||||||||
Synonyms | C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000119139 | ||||||||||||||||||||||
Encoded Proteins |
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2 (zona occludens 2)
tight junction protein 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:69121264-69255208 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q21.11 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME |
Signaling by Hippo pathway
Apoptotic cleavage of cell adhesion proteins pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Apoptosis pathway
Signal Transduction pathway
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KEGG |
Vibrio cholerae infection pathway
Tight junction pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional repression
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.50382 | ||||||||||||||||||||||
RefSeq | NM_001170414 NM_001170415 NM_001170416 NM_001170630 NM_004817 NM_201629 XM_005252311 XM_005252312 XM_005252313 XM_005252314 XM_005252315 XM_006717324 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS55314 CCDS55315 CCDS55316 CCDS55317 CCDS6627 CCDS6628 | ||||||||||||||||||||||
HPRD | 06369 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||