Version 5.4
Homo sapiens Gene: TP63
Summary
InnateDB Gene IDBG-69487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP63
Gene Name tumor protein p63
Synonyms AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
Species Homo sapiens
Ensembl Gene ENSG00000073282
Encoded Proteins
IDBP-69489
tumor protein p63
IDBP-69493
tumor protein p63
IDBP-69495
tumor protein p63
IDBP-245607
tumor protein p63
IDBP-245609
tumor protein p63
IDBP-245611
tumor protein p63
IDBP-386575
tumor protein p63
IDBP-386577
tumor protein p63
IDBP-386579
tumor protein p63
IDBP-386581
tumor protein p63
IDBP-386584
tumor protein p63
IDBP-386586
tumor protein p63
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21367858
TP63 is a crucial regulator downstream of TLR3 in Poly(I:C)-induced signalling. TP63 activates the signalling of both extrinsic and intrinsic apoptosis pathways in endothelial cells through death receptors and mitochondria.
InnateDB Annotation from Orthologs
Summary
PMID 21367858
[Mus musculus] Trp63 is a crucial regulator downstream of Tlr3 in Poly(I:C)-induced signalling. Trp63 activates the signalling of both extrinsic and intrinsic apoptosis pathways in endothelial cells through death receptors and mitochondria.
Entrez Gene
Summary This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:189631416-189897279
Strand Forward strand
Band q28
Transcripts
ENST00000264731 ENSP00000264731
ENST00000320472 ENSP00000317510
ENST00000354600 ENSP00000346614
ENST00000392463 ENSP00000376256
ENST00000392461 ENSP00000376254
ENST00000392460 ENSP00000376253
ENST00000440651 ENSP00000394337
ENST00000418709 ENSP00000407144
ENST00000434928 ENSP00000401661
ENST00000449992 ENSP00000387839
ENST00000456148 ENSP00000389485
ENST00000437221 ENSP00000392488
ENST00000486398
ENST00000460036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 159 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 159 [view]
Protein-Protein 138 [view]
Protein-DNA 17 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0050699 WW domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001302 replicative cell aging
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001942 hair follicle development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002064 epithelial cell development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219 Notch signaling pathway
GO:0007283 spermatogenesis
GO:0007389 pattern specification process
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008544 epidermis development
GO:0009887 organ morphogenesis
GO:0009954 proximal/distal pattern formation
GO:0010165 response to X-ray
GO:0010259 multicellular organismal aging
GO:0010332 response to gamma radiation
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030850 prostate gland development
GO:0030855 epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0034644 cellular response to UV
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043589 skin morphogenesis
GO:0043616 keratinocyte proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048485 sympathetic nervous system development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048807 female genitalia morphogenesis
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051402 neuron apoptotic process
GO:0060157 urinary bladder development
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 establishment of skin barrier
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000381 negative regulation of mesoderm development
GO:2000773 negative regulation of cellular senescence
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022510
View Gene Order
ENSBTAG00000015460
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
tap63pathway
Validated transcriptional targets of TAp63 isoforms
p63pathway
p63 transcription factor network
Cross-References
SwissProt Q9H3D4
TrEMBL
UniProt Splice Variant
Entrez Gene 8626
UniGene Hs.137569
RefSeq NM_001114978 NM_001114979 NM_001114980 NM_001114981 NM_001114982 NM_003722 XM_005247843 XM_005247844 XM_005247846
HUGO HGNC:15979
OMIM 603273
CCDS CCDS3293 CCDS46976 CCDS46977 CCDS46978 CCDS46979 CCDS46980
HPRD 04469
IMGT
EMBL AB010153 AB016072 AB016073 AB042841 AF061512 AF075428 AF075429 AF075430 AF075431 AF075432 AF075433 AF091627 AF116756 AF116757 AF116758 AF116759 AF116760 AF116761 AF116762 AF116763 AF116764 AF116765 AF116766 AF116767 AF116768 AF116769 AF116770 AF116771 AF124528 AF124529 AF124530 AF124531 AF124532 AF124533 AF124534 AF124535 AF124536 AF124537 AF124538 AF124539 AF124540 AJ315499 AY339663 AY339664 AY341142 AY341143 AY341144 AY341145 AY342152 AY342153 AY342154 BC039815 Y16961
GenPept AAC24830 AAC43038 AAC62633 AAC62634 AAC62635 AAC62636 AAC62637 AAC62638 AAF43486 AAF43487 AAF43488 AAF43489 AAF43490 AAF43491 AAF43492 AAF43493 AAF61624 AAG45607 AAG45608 AAG45609 AAG45610 AAG45611 AAG45612 AAH39815 AAQ63448 AAQ63449 AAQ63450 AAQ63451 AAQ63452 AAQ63453 AAQ63454 BAA32433 BAA32592 BAA32593 BAB20591 CAA76562 CAC48053
RNA Seq Atlas 8626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca