Homo sapiens Gene: KDM5C
Summary
InnateDB Gene IDBG-69550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM5C
Gene Name lysine (K)-specific demethylase 5C
Synonyms DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ; MRXSJ; SMCX; XE169;
Species Homo sapiens
Ensembl Gene ENSG00000126012
Encoded Proteins
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
lysine (K)-specific demethylase 5C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:53191321-53225422
Strand Reverse strand
Band p11.22
Transcripts
ENST00000349663 ENSP00000344004
ENST00000375401 ENSP00000364550
ENST00000375383 ENSP00000364532
ENST00000375379 ENSP00000364528
ENST00000404049 ENSP00000385394
ENST00000452825 ENSP00000445176
ENST00000429877 ENSP00000409757
ENST00000428012 ENSP00000407277
ENST00000477109
ENST00000497100
ENST00000465402
ENST00000481369
ENST00000497995
ENST00000495519
ENST00000467093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 28 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032453 histone demethylase activity (H3-K4 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034720 histone H3-K4 demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HDMs demethylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P41229
TrEMBL
UniProt Splice Variant
Entrez Gene 8242
UniGene Hs.631768
RefSeq NM_001146702 NM_001282622 NM_004187 XM_005262035
HUGO HGNC:11114
OMIM 314690
CCDS CCDS55417 CCDS14351 CCDS65269
HPRD 02442
IMGT
EMBL AK304732 AL139396 BC054499 CH471154 L25270 Z29650
GenPept AAA61302 AAH54499 BAG65494 CAA82758 CAI39836 CAI39837 CAI39838 EAW93145
RNA Seq Atlas 8242